1825: — First State Senator to become Missouri Governor — Abraham J. Williams

1912-1968: – First to reach the 40- and then 50- year mark as a state senator — Michael Kinney

1960: — First African-American Senator — Theodore McNeal

1972: — First Female Senator — Mary Gant

1977: — First African-American Female Senator – Gwen Giles

1984: — First Female Senate President (Lt. Gov.) – Harriet Woods, elected to the Senate in 1976

1988: — First African-American Majority Floor Leader – J. B. "Jet" Banks

1994: — First former NFL quarterback to serve as state senator – Bill Kenney

1998: — First State Senator to end service due to term limits — Bill McKenna

1998: — First Internet streaming of Senate debate

2002: — First African-American Assistant Minority Floor Leader – Maida Coleman

2004: — First African-American Female Minority Floor Leader – Maida Coleman

2005: — First Senate podcast of an audio program

2005: — First streaming video of a featured Senate program